Vancomycin Grafted Polydopamine Coated Silver Nanoparticles for Enhanced Antibacterial Action Against Vancomycin-Resistant Bacteria E. Faecalis.

摘要

A wide variety of pathogens causing nosocomial infections have emerged, showing resistance towards commonly used antimicrobial agents. Nosocomial infections are rapidly emerging as a severe threat leading to high morbidity and mortality. In this study, we have introduced Vancomycin grafted polydop-amine(pDA) coated silver nanoparticles (AgNPs) to combat vancomycin-resistant bacterial species Enterococci faecalis ( E.faecalis). The prepared nanoparticles were characterized by High Resolution-Transmission Electron Microscopy (HR-TEM), Energy Dispersive X-ray Spectroscopy (EDS), Ultraviolet (UV) Visible spectroscopy and Attenuated Total Reflection-Fourier Transform Infrared spectroscopy (ATR-FTIR). The nanoparticles were 33 nm in size as revealed by HR-TEM. Antimicrobial assays were conducted to investigate the antimicrobial activity of vancomycin-pDA@AgNPs against E. faecalis by a zone of inhibition method. The vancomycin-pDA@AgNPs exhibited good bactericidal activity against vancomycin-resistant E. faecalis.