Section 5. Medical science: ANTI-REMODELING EFFICIENCY OF PREPARATIONS SUCH AS PERINDOPRIL, VEROSHPIRON AND BISOPROLOL APPLIED TO PATIENTS WITH DIASTOLIC CHRONIC HEART FAILURE AND METABOLIC SYNDROME

摘要

The aim of this work is to study the anti-remodeling efficiency of complex pharmacotherapy of diastolic left ventricular dysfunction of chronic heart failure (CHF) by use of perindopril, veroshpiron and bisoprolol in patients with metabolic syndrome (MS). The study involved 76 male patients with chronic heart failure (CHF) II-III FC, with post infarction cardiosclerosis. Depending on the components of MS the patients were divided into 3 groups: 1~(st) group (n = 27), patients without MS; Group II (n = 24, patients with a combination of dyslipidemia (DLP) with abdominal obesity (AO) and arterial hypertension (AH); Group III (n = 25), patients with a combination of AO, AH and DLP with diabetes 2. A three-month treatment with an implement of the Perindopril, Bisoprolol and Veroshpiron combination in patients suffering from CHF without MS promotes regression of non-adaptive remodeling of myocardial left ventricular and improvement of diastolic function of the heart. The most marked resistance against therapy exists when there is a combination of AO, AH and DLP with diabetes 2 types.