Section 5. Medical science: THE ACTIVITY OF MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN PATIENTS WITH SCLERODERMA

摘要

A study of the level of matrix me talloproteinases (MMP-2, MMP-7, MMP-9) in the serum of 29 patients with systemic and 35 patients with limited scleroderma showed a decrease in their activity against the increase in their inhibitors (TIMP-1 and TIMP-2), especially in patients with systemic scleroderma. The level of serum TGF-β1 increased significantly, and was also more pronounced in patients with systemic scleroderma. Correlation analysis of the relationship between MMPs and TIMP parameters with TGF-β showed strong feedback with MMP-2, MMP-7 and MMP-9, a direct strong association with TIMP-1 and TIMP-2, more pronounced in the systemic course of the disease.