Green Approach for Preparation of New Hybrids of 5-Substituted-1H-Tetrazoles Using Novel Recyclable Nanocatalyst based on Copper(II) Anchored onto Glucosamine Grafted to Fe3O4@SiO2

摘要

The novel copper(II) ions decorated Fe3O4@SiO2 composite magnetic spheres were synthesized by grafting copper(II) ions onto glucosamine modified Fe3O4@SiO2 NPs. The magnetic Fe3O4@SiO2 -TCT-GA-Cu(II) catalyst were characterized by varies physicochemical techniques such as FT-IR, FE-SEM, TEM, DLS, XRD, EDX, VSM, TGA, VSM, ICP, and UV-Vis. The catalytic performance of this novel catalyst was studied in the green preparation of 5-substituted 1H-tetrazole based hybrids via three-component and one-pot reaction of sodium azide, hydroxylamine hydrochloride, and various aldehydes in water and ethylene glycol, as a green solvent mixture. This green protocol provides significant advantages such as non-vigorous conditions, short reaction times, outstanding yield of desired tetrazoles, minimizing of chemical waste, wide-ranging sub- strate, quick and efficient work-up procedure and using environmentally benign, durable, cost effective, magnetically separable, reusable nanocatalyst.