Copper-Catalyzed Remote C5-Selective Chlorination of 8-Amidoquinolines Using Sulfonyl Chlorides as Cl Source

摘要

Sulfonyl chloride has been rarely used as Cl source in transition metal-catalyzed C-H functionalizations. We report the unprece- dented copper-catalyzed remote C5-chlorination of substituted 8-amidoquinolines with sulfonyl chloride under 1 atm oxygen. 10 sulfonyl chlorides and 15 substituted 8-amidoquinolines were tested, generating moderate to high yields. The catalytic system showed high regio-selectivity, as well as good func- tional group tolerance.