One-pot Suzuki Coupling-Knoevenagel Condensation Tandem Reaction Catalyzed by a Recyclable Magnetic Bifunctional Catalyst

摘要

A novel magnetic nanoparticle-supported bifunctional catalyst NH-Pd(0)@MNP was prepared and its activity was evaluated in one-pot Suzuki coupling-Knoevenagel condensation tandem reaction. A series of biaryl derivatives were synthesized via sequential Suzuki coupling-Knoevenagel condensation in ethanol/water medium under phosphine-free conditions. Meanwhile, the catalyst could be easily separated by an external magnetic field, and could be reused several times without remarkable loss of catalytic activity.