A Simple and High-Accuracy PID-Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer

摘要

Magnetic hyperthermia is very promising cancer therapy in which heating temperature is expected to be a key determinant for its success. Herein, we present a simple, real-time, and high-accuracy proportional-integral-derivative-based temperature control system for magnetic hyperthermia using widely-used induction heater and fiber optic thermometer. Our in vitro result shows that the temperature of clinically-approved Resovist (R) (0.5 ml) was accurately controlled with very small overshoot (e.g., 45.0 +/- 0.07 degrees C and 55.0 +/- 0.11 degrees C for low- and high-temperature magnetic hyperthermia). Our system has the potential to be used for magnetic hyperthermia either alone or together with other cancer treatment modalities for basic and clinical studies. (c) 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.