In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM**

摘要

The present study describes mono substituted indeno[1,2-b] quinolines (3a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 ug/mL) and show similar cytotoxicity (14.3% to 19.8%) to cells such as controls. More- over, the mono substituted indeno[1,2-b]quinoline amines (3a– c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 ug/mL and 250 ug/mL. The compounds can also bind to DNA in the groove binding mode with a