Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis-Amidic Triazole Hybrid Compounds via One-Pot Sequential Six/Seven Component Ugi-Click Reaction

摘要

Synthesis of bis(indolyl)methane/dihydropyrimidinone based bis-amide-triazole hybrid compounds has been achieved via one-pot six/seven-component sequential Ugi-Click reaction. Two molecular libraries of anti-bacterial compounds containing significant pharmacophoric nuclei were synthesized in good yield and purity using green solvent, mild reaction conditions with atom economy by structural modifications in three independent starting materials.