An Overview of the Synthesis of Biologically Active Cyclodepsipeptides

摘要

Cyclodepsipeptide are a class of natural cyclic peptides that have a wide range of biological activities,hence the potential to be developed as new drug candidates.Cyclodpesipeptides comprise a backbone of amide bonds and at least one ester moiety,thus are complex and challenging to synthesis.Generally,cyclodepsipeptides are synthesised via solid-phase peptide synthesis,solution-phase or a combination of solid and solution-phase.Currently,solid-phase peptide synthesis is more in demand,but it also has several challenges in its application especially for the cyclodepsipeptide that contains N-methylated residues,as well as solution-phase peptide synthesis tends to have a longer reaction step.Therefore,the combination of solid and solution-phase peptide synthesis is a better alternative.This review discusses the synthetic strategies for cyclodepsipeptides including the preparation of precursor and macrocyclization.