Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Tanriover Mine Durusu; Doganay Hamdi Levent; Akova Murat; Guner Hatice Rahmet; Azap Alpay; Akhan Sila; Kose Sukran; Erdinc Fatma Sebnem; Akalin Emin Halis; Tabak Omer Fehmi; Pullukcu Husnu; Batum Ozgur; Yavuz Serap Simsek; Turhan Ozge; Yildirmak Mustafa Taner; Koksal Iftihar; Tasova Yesim; Korten Volkan; Yilmaz Gurdal; Celen Mustafa Kemal; Altin Sedat; Celik Ilhami; Bayindir Yasar; Karaoglan Ilkay; Yilmaz Aydin; Ozkul Aykut; Gur Hazal; Unal Serhat

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Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

机译：灭活的全年疾病SARS-COV-2疫苗（Coronavac）的疗效和安全性：在土耳其的双盲，随机，安慰剂控制，第3阶段试验的临时结果

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Background CoronaVac, an inactivated whole-virion SARS-CoV-2 vaccine, has been shown to be well tolerated with a good safety profile in individuals aged 18 years and older in phase 1/2 trials, and provided a good humoral response against SARS-CoV-2. We present the interim efficacy and safety results of a phase 3 clinical trial of CoronaVac in Turkey.

机译：背景CoronaVac是一种灭活的SARS-CoV-2全病毒疫苗，在1/2期试验中，18岁及18岁以上的个体表现出良好的耐受性和安全性，并对SARS-CoV-2提供了良好的体液应答。我们介绍了在土耳其进行的CoronaVac 3期临床试验的中期疗效和安全性结果。

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《The Lancet》 |2021年第10296期|共10页
作者
Tanriover Mine Durusu; Doganay Hamdi Levent; Akova Murat; Guner Hatice Rahmet; Azap Alpay; Akhan Sila; Kose Sukran; Erdinc Fatma Sebnem; Akalin Emin Halis; Tabak Omer Fehmi; Pullukcu Husnu; Batum Ozgur; Yavuz Serap Simsek; Turhan Ozge; Yildirmak Mustafa Taner; Koksal Iftihar; Tasova Yesim; Korten Volkan; Yilmaz Gurdal; Celen Mustafa Kemal; Altin Sedat; Celik Ilhami; Bayindir Yasar; Karaoglan Ilkay; Yilmaz Aydin; Ozkul Aykut; Gur Hazal; Unal Serhat;
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作者单位

Hacettepe Univ Sch Med Dept Internal Med Ankara Turkey;

Univ Hlth Sci Istanbul Umraniye Training &

Res Hosp Istanbul Prov Hlth Directorate Dept;

Hacettepe Univ Sch Med Dept Infect Dis &

Clin Microbiol Ankara Turkey;

Ankara Yildirim Beyazit Univ Ankara City Hosp Dept Infect Dis &

Clin Microbiol Ankara Turkey;

Kocaeli Univ Sch Med Dept Infect Dis &

Clin Microbiol Kocaeli Turkey;

Izmir Univ Hlth Sci Tepecik Training &

Res Hosp Izmir Prov Hlth Directorate Dept Infect Dis;

Ankara Numune Training &

Res Hosp Ankara Prov Hlth Directorate Turkish Republ Minist Hlth Dept;

Bursa Uludag Univ Bursa Uludag Univ Hosp Hlth Applicat &

Res Ctr Dept Infect Dis &

Clin;

Istanbul Univ Cerrahpasa Cerrahpasa Med Sch Dept Infect Dis &

Clin Microbiol Istanbul Turkey;

Ege Univ Sch Med Dept Infect Dis &

Clin Microbiol Izmir Turkey;

Univ Hlth Sci Dr Suat Seren Chest Dis &

Surg Training &

Res Hos Izmir Prov Hlth Directorate Dept;

Istanbul Univ Istanbul Sch Med Dept Infect Dis &

Clin Microbiol Istanbul Turkey;

Akdeniz Univ Sch Med Dept Infect Dis &

Clin Microbiol Antalya Turkey;

Prof Dr Cemil Tascioglu City Hosp Istanbul Prov Hlth Directorate Turkish Republ Minist Hlth Dept;

Acibadem Univ Atakent Hosp Dept Infect Dis &

Clin Microbiol Istanbul Turkey;

Cukurova Univ Balcali Hosp Dept Infect Dis &

Clin Microbiol Hlth Applicat &

Res Ctr Adana;

Marmara Univ Sch Med Dept Infect Dis &

Clin Microbiol Istanbul Turkey;

Karadeniz Tech Univ Sch Med Dept Infect Dis &

Clin Microbiol Trabzon Turkey;

Dicle Univ Sch Med Dept Infect Dis &

Clin Microbiol Diyarbakir Turkey;

Univ Hlth Sci Istanbul Yedikule Chest Dis &

Thorac Surg Trainin Istanbul Prov Hlth Directorate;

Kayseri City Training &

Res Hosp Turkish Republ Minist Hlth Dept Infect Dis &

Clin Microbiol;

Inonu Univ Turgut Ozal Hlth Ctr Dept Infect Dis &

Clin Microbiol Malatya Turkey;

Gaziantep Univ Sahinbey Res &

Applicat Ctr Dept Infect Dis &

Clin Microbiol Gaziantep Turkey;

Ataturk Chest Dis &

Thorac Surg Training &

Res Ho Ankara Kecioren Sanat Ankara Prov Hlth;

Ankara Univ Fac Vet Med Dept Virol Ankara Turkey;

Hacettepe Univ Sch Med Dept Med Microbiol Ankara Turkey;

Hacettepe Univ Sch Med Dept Infect Dis &

Clin Microbiol Ankara Turkey;

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正文语种 eng
中图分类医药、卫生;
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Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

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