Catalytic Asymmetric Reduction of alpha-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates

摘要

A catalytic enantioselective reduction of alpha-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral alpha-trifluoromethylated amines in high yields and with excellent enantioselectivities (up to 98% yield and 96% ee) under mild conditions.