Site-Selective Acylations of alpha- and beta-Hydroxyamides in Complex Molecules: Application of Template-Driven Acylation to Disaccharides and a Glycopeptide

摘要

Site-selective acylations of alpha-and beta-hydroxyamides in complex polyols are described. The combination of a pyridine aldoxime ester and Zn(OTf)(2) facilitates the acylation of two types of N-glycolyl disaccharides, namely, Gal-GlcNGc and Neu5Gc-Gal, both of which are partial structures of polysaccharides responsible for biological actions, with highly site-selective modifications achieved. Furthermore, biotinylation, one of the most important techniques in chemical biology, is used to site-selectively acylate the beta psi-hydroxyl group in a glycopeptide.