Combination therapy with semaglutide and rosiglitazone as a synergistic treatment for diabetic retinopathy in rodent animals

Yang Xiaoxi; Wu Shuduan; Feng Zhizhen; Yi Guoguo; Zheng Yuxing; Xia Zhaoxia

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Combination therapy with semaglutide and rosiglitazone as a synergistic treatment for diabetic retinopathy in rodent animals

机译：用Semlutide和Rosiglitazone的组合疗法作为啮齿动物动物患有糖尿病视网膜病变的协同治疗

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Objective: To investigate the protective efficacies and potent mechanisms of combination therapy with semaglutide and rosiglitazone (RSG) on the high-glucose incubated human ARPE-19 cells and diabetic retinopathy (DR) model rats.

机译：目的：探讨塞马鲁肽和罗格列酮（RSG）联合治疗对高糖培养的人ARPE-19细胞和糖尿病视网膜病变（DR）模型大鼠的保护作用及其机制。

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来源
《Life sciences 》 |2021年第1期| 共11页
作者
Yang Xiaoxi; Wu Shuduan; Feng Zhizhen; Yi Guoguo; Zheng Yuxing; Xia Zhaoxia;
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作者单位

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

Sun Yat Sen Univ Dept Ophthalmol Affiliated Hosp 6 Guangzhou 51000 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Semaglutide; Rosiglitazone; Diabetic retinopathy; Combination therapy; Rodent animals;

机译：塞马鲁肽;罗格列酮;糖尿病性视网膜病变;联合治疗;啮齿动物;

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1. Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis [J] . Wan-chun Ye1, Jian-zhong Ye23, Cheng Zheng4, 中草药：英文版 . 2019 ,第002期
2. Mayombian ethnic,vegetables low intake,insulin treatment,diabetic nephropathy and severe diabetic retinopathy are determinants of blindness in diabetic Africans [J] . Mvitu Muaka Moise, Longo-Mbenza Benjamin, Cibanda Yokobo Enoch, 国际眼科杂志：英文版 . 2013 ,第005期
3. Mayombian ethnic, vegetables low intake, insulin treatment, diabetic nephropathy and severe diabetic retinopathy are determinants of blindness in diabetic Africans [J] . Mvitu Muaka Moise, Longo-Mbenza Benjamin, Cibanda Yokobo Enoch, 国际眼科杂志：英文版 . 2013 ,第005期
4. Relationship between modified homeostasis model assessment/correlative serum factors and diabetic retinopathy among type 2 diabetics with insulin therapy in Guangzhou, China [J] . Li, Hu, Dong-Hao, 国际眼科杂志：英文版 . 2014 ,第003期
5. Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model [J] . Jesper G. Madsen, Martin N. Skov, Kasper Hansen, 生物医学工程（英文） . 2021 ,第012期
6. Effectiveness of AR-13154 monotherapy and combination therapy in animal models of wet age-related macular degeneration and proliferative diabetic retinopathy [J] . Cheng-Wen Lin, Jill M Sturdivant, Mitchell A deLong, Investigative ophthalmology & visual science . 2016 ,第12期

机译：AR-13154单一疗法和联合疗法在湿性年龄相关性黄斑变性和增生性糖尿病视网膜病变动物模型中的有效性
7. Effectiveness of AR-13154 monotherapy and combination therapy in animal models of wet age-related macular degeneration and proliferative diabetic retinopathy [J] . Lin Cheng-Wen, Sturdivant Jill M., deLong Mitchell A., Investigative ophthalmology & visual science . 2016 ,第12期

机译：AR-13154单药治疗和组合治疗在湿年龄相关性黄斑和增殖性糖尿病视网膜疗法动物模型中的有效性
8. Combination therapy with Exendin-4 and islet transplantation as a synergistic treatment for diabetic nephropathy in rats [J] . Xie Zhijuan, Chen Zhong, Chen Jianying Life sciences . 2021 ,第1期

机译：用Exendin-4和胰岛移植的组合治疗作为大鼠糖尿病肾病的协同治疗
9. Outcomes of combination treatments in refractory neovascular glaucoma. A retrospective review in patients with advanced proliferative diabetic retinopathy [C] . Ramoa R., Juberfas J.R., Manzanas L, International Symposium on Ocular Pharmacology and Therapeutics . 2013

机译：难治性新生血管青光眼组合治疗的结果。晚期增殖性糖尿病视网膜病变患者的回顾性综述
10. Combined Cell and Gene Therapy towards the Treatment of Age-related Macular Degeneration and Diabetic Retinopathy [D] . Petrou, Sabiha Hacibekiroglu. 2018

机译：细胞和基因联合疗法治疗老年性黄斑变性和糖尿病性视网膜病
11. Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats [O] . Servet Kavak, Lokman Ayaz, Mustafa Emre 2012

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12. Risk factors for renal replacement therapy in the Early Treatment Diabetic Retinopathy Study (ETDRS), Early Treatment Diabetic Retinopathy Study Report No. 26 [O] . Cusick Michael, Chew Emily Y., Hoogwerf Byron, 2004

机译：早期糖尿病性视网膜病变研究（ETDRS），早期糖尿病性视网膜病变研究报告第26号中肾脏替代治疗的危险因素
13. Atypical and Typical Winter Depressive Symptoms and Responsiveness to Light Therapy, Cognitive-Behavioral Therapy, or Combination Treatment [R] . Johnson, L. G. , Rohan, K. J. 2005

机译：非典型和典型的冬季抑郁症状和对光疗法，认知行为疗法或综合治疗的反应

Combination therapy with semaglutide and rosiglitazone as a synergistic treatment for diabetic retinopathy in rodent animals

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