A unified multi-activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)

Li Shidong; Miyamoto Curtis; Wang Bin; Giaddui Tawfik; Micaily Bizhan; Hollander Andrew; Weiss Stephanie E.; Weaver Michael

首页> 外文期刊>Medical Physics >A unified multi-activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)

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A unified multi-activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)

机译：在整个剂量范围内计算统一的多激活（UMA）模型，用于计算立体定向体放射治疗（SBRT），高剂量率近距离放射治疗（HDRB）和立体定向放射术（SRS）中的等效剂量范围

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Purpose Application of linear-quadratic (LQ) model to large fractional dose treatments is inconsistent with observed cell survival curves having a straight portion at high doses. We have proposed a unified multi-activation (UMA) model to fit cell survival curves over the entire dose range that allows us to calculate EQD2 for hypofractionated SBRT, SRT, SRS, and HDRB.

机译：目的将线性二次（LQ）模型应用于大剂量分次剂量治疗，与观察到的细胞存活曲线在高剂量下呈直线部分不一致。我们提出了一个统一的多激活（UMA）模型，以拟合整个剂量范围内的细胞存活曲线，从而计算低分次SBRT、SRT、SRS和HDRB的EQD2。

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《Medical Physics》 |2021年第4期|共12页
作者
Li Shidong; Miyamoto Curtis; Wang Bin; Giaddui Tawfik; Micaily Bizhan; Hollander Andrew; Weiss Stephanie E.; Weaver Michael;
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作者单位

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hosp &

Med Sch Dept Radiat Oncol Philadelphia PA 19140 USA;

Temple Univ Hlth Syst Dept Radiat Oncol Fox Chase Canc Ctr Philadelphia PA USA;

Temple Univ Hlth Syst Dept Neurosurg Philadelphia PA USA;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
EQD2; HDR; Radiobiological Outcome modeling; SBRT; SRS;

机译：EQD2;HDR;放射生物学结果建模;丁苯橡胶;SRS;

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2. Quantification of incidental dose to potential clinical target volume (CTV) under different stereotactic body radiation therapy (SBRT) techniques for non-small cell lung cancer - Tumor motion and using internal target volume (ITV) could improve dose [J] . Jin JY, Ajlouni M, Chen Q, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2007,第2期

机译：针对非小细胞肺癌，在不同的立体定向放射治疗（SBRT）技术下对潜在临床目标体积（CTV）的偶然剂量进行量化-肿瘤运动和使用内部目标体积（ITV）可以提高剂量
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机译：基于线性二次和通用存活曲线模型重新审视等效均匀剂量的形式主义，在高剂量立体定向体放射疗法中
4. Stereotactic Body Radiation Therapy and High-Dose-Rate Brachytherapy Boost in Combination With Intensity Modulated Radiation Therapy for Localized Prostate Cancer: A Single-Institution Propensity Score Matched Analysis [J] . Chen William C., Li Yun, Lazar Ann, International Journal of Radiation Oncology, Biology, Physics . 2021,第2期

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5. Image-guided stereotactic body radiation therapy using a low-Z target imaging beam line and a high dose rate unflattened beam [C] . O. Gayou World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

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6. A comparative study of quality of life in patients with low-and intermediate-risk prostate cancer treated at a single institution: Stereotactic radiotherapy vs. high dose-rate brachytherapy monotherapy vs. high dose-rate brachytherapy boost [D] . Helou, Joelle. 2017

机译：单一机构治疗的中低危前列腺癌患者生活质量的比较研究：立体定向放疗与高剂量率近距离放射疗法单药疗法与高剂量率近距离放射疗法增强
7. Public interest in stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) in the United States [O] . Timothy D. Malouff, Danushka Seneviratne, William C. Stross, 2020

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8. A unified multi‐activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS) [O] . Shidong Li, Curtis Miyamoto, Bin Wang, 2021

机译：细胞存活曲线的统一的多激活（UMA）模型在整个剂量范围，用于计算在体部立体定向放射治疗（SBRT），高剂量率近距离（HDRB）和立体定向放射外科等效剂量（SRS）
9. Survival of Chinese Hamster Ovary Cells Following Ultrahigh Dose Rate Electronand Bremsstrahlung Radiation [R] . Holahan, P. K., Meltz, M. L. 1990

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A unified multi-activation (UMA) model of cell survival curves over the entire dose range for calculating equivalent doses in stereotactic body radiation therapy (SBRT), high dose rate brachytherapy (HDRB), and stereotactic radiosurgery (SRS)

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