Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[~(18)F]fluoro-L-amino suberate

摘要

System xc- (SX_c-) has emerged as a new biological target for PET studies to detect oxidative and excitotoxic stress. Notably, applications have, thus far, been limited to tumour imaging although Sx_c~-) may play a major role in neuro-degeneration. The synthesis procedures of tosylate precursor and its translation to Sx_c- PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described. A brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.