Species distribution and antifungal susceptibilities of bloodstreamCandidaisolates: a nine-years single center survey

摘要

This study analyzed the epidemiology of bloodstream infections due toCandidaspp. in a tertiary referral hospital of Ancona, Italy, and their susceptibility to antifungals. The retrospective observational study from January 2010 to December 2018 identified 504 episodes of candidemia in 461 patients. AlthoughCandida albicansremained the species most frequently isolated,Candidaspp. other thanC. albicanscaused 49% of the overall episodes of candidemia. According to CLSI interpretation, most of the isolates resulted susceptible to antifungals. Azolesvs Candida tropicalisrepresented an exception. Echinocandin non-susceptibility was rare across the species. In conclusion, with the exception ofC. tropicalis, the isolation of a non-susceptibleCandidastrains against azoles, echinocandins and amphotericin B was a rare event.