STUDIES ON EVALUATION OF HYPOGLYCEMIC EFFECT OF AQUEOUS EXTRACT OF ALOE VERA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

摘要

Hypoglycemic effect of aqueous extract ofAloe vera (L.) Burm.f. was evaluated in streptozotodn induced diabetic nits. Diabetes was induced in Wister albino female rats experimentally by using Streptozotodn at the dose rate of 40 mg/kg. The various groups in this study included normal control (Group I), diabetic control (Group II), diabetic rats treated with glibenclamide at the dose of600 mg/kg (Group III), diabetic rats treated with Aloe vera at the dose of300 mg/kg (Group IV) and diabetic rats treated with com bination of Aloe vera (150 mg/kg) and glibenclamide (300 mg/kg) (Group V). By estimating the serum glucose levels 72 hours post STZ injection the diabetes was confirmed. The serum samples were collected at various intervals and subjected forthe estimation of glucose using biochemical analyzer. The serum glucose values in diabetic control ' rats were significantly higher (P< 0.001) on all the intervals of study in comparison with normal control rats. The mean (± SE) serum glucose levels inthe diabetic rats treated with Glibenclamide at the dose of600 mg/kg body weight showed a gradual and significant reduction (P< 0.001) from day 3 to day 45 when compared to diabetic control rats. There was a progressive decrease in the mean (± SE) serum glucose values in the diabetic rats treated with Aloe vera individually and in Aloe vera & Glibenclamide combined treatment group. However, the combined treatment of Aloe vera (150 mg/kg) with glibenclamide (300 mg/kg) revealed better hypoglycemic effect which indicated a synergistic effect of Aloe vera and glibenclamide when used in combination.