FACILE SYNTHESIS OF SPIROOXINDOLES VIA AN ENANTIOSELECTIVE ORGANOCATALYZED SEQUENTIAL REACTION OF OXINDOLES WITH YNONE

摘要

The reaction of oxindole la with phenylprop-2-yn-l-one (2a) was promoted by the chiral multifunctional phosphine catalyst 4a derived from (S)-valine, giving spirooxindole 3a in good yield and high enantioselectivity. The obtained spirooxindole forms a common scaffold of a vast number of natural products exhibiting various biological activities.