Immunity, immunotherapy, and rectal cancer: A clinical and translational science review

摘要

Abbreviations: 5-FU = 5-Fluorouracil; APC = antigen-presenting cell; ATP = adenosine triphosphate; CapOx = Capecitabine, Oxaliplatin; cCR = complete clinical response; CRC = colorectal cancer; CRT = chemoradiation therapy; ctDNA = circulating tumor DNA; CTL = cytotoxic Tcell; CTLA-4 = cytotoxic T-lymphocyte-associated protein 4; DAMPs = damage-associated molecular patterns; DFS = disease-free survival; FOLFIRI = 5-FU, Leucovorin, Irinotecan; FOLFOX = 5-FU, Leucovorin, Oxaliplatin; HMGB1 = high mobility group protein B1; ICI = Immune