Increased p300/CBP expression in acute respiratory distress syndrome is associated with interleukin-17 and prognosis

摘要

Purpose Transcription co-activator p300/CBP, a histone acetyltransferase, has a central role in tumours, inflammation and neurodegenerative diseases. We investigated the effect of p300/CBP and its association with various IL-17-related indicators and prognosis in patients with acute respiratory distress syndrome (ARDS). Materials and Methods We enrolled 45 adult ARDS patients who were followed for 28 days and 22 healthy controls. The mRNA expression of p300, CBP, ROR gamma t and Foxp3 and the plasma levels of several cytokines were measured. Result The mRNA levels of p300, CBP and ROR gamma t, and plasma concentration of IL-17, IL-6, were higher in acute ARDS patients (P < 0.05) compared with controls, and the mean levels of p300, CBP and IL-6 in non-survivors were higher than in survivors (P < 0.05). The expression of p300 was associated with the level of ROR gamma t, IL-17 and disease prognosis. Conclusion The levels of p300, ROR gamma t mRNA and plasma concentration of IL-6 and IL-17 in acute ARDS patients were increased compared with controls. Increased p300/CBP expression may be an independent risk factor for 28-day mortality in ARDS.