Editorial Comment: The Impact of Pseudoephedrine and Antihistamine on Lower Urinary Tract Symptoms in Male Patients with Rhinitis: A Prospective Randomized Study

摘要

Acute urinary retention has association with the use of drugs with anticholinergic activity (e.g., antihistamine, alpha-adrenoceptor agonists, antipsychotic drugs, antidepressant agents, opioids and anesthetics, benzodiazepines, and calcium-channel antagonists). Elderly patients are at higher risk of drug-induced urinary retention happening because of existing comorbidities such as benign prostatic hyperplasia, diabetes mellitus, neurological diseases, and the use of other concomitant medications that could reinforce the impairing effect on micturition. We congratulated Lee CC et al. conducted the prospective randomized study to investigate the impact of pseudoephedrine and antihistamine on lower urinary tract symptoms (LUTSs) in "asymptomatic" male patients with rhinitis. The main conclusion was that although the effect of both medications on LUTS was limited, pseudoephedrine worsened International Prostate Symptom Score - Total (1PSST) in elderly men, whereas antihistamines worsened IPSS-V in younger men. In self-unaware voiding dysfunction males with IPSS-T>7, pseudoephedrine may cause more Post-voiding residual urine volume (PVR).