Solubility of acetaminophen in 1-propanol + water mixtures atT=293.2-313.2 K

摘要

The mole fraction solubilities of acetaminophen (ACP) were measured in the binary solvent mixtures of {1-propanol + water} atT = 293.2-313.2 K. The Jouyban-Acree, Jouyban-Acree-van't Hoff, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) and modified Wilson models as well as a non-linear model presented by Machatha et al. were used to correlate the measured equilibrium solubilities. Furthermore, the experimental data were predicted with five predictive models, i.e. Yalkowsky, extended Yalkowsky as well as trained versions of Yalkowsky, Jouyban-Acree and Jouyban-Acree-Hansen models. Moreover, the apparent standard molar Gibbs energy, enthalpy, and entropy of dissolution and mixing (Delta Gsoln circle,Delta Hsoln circle,Delta Ssoln circle,Delta Gmix circle,Delta Hmix circle,Delta Smix circle) of ACP in {1-propanol (1) + water (2)} mixtures were calculated at mean harmonic temperatureT(hm) = 303 K based on van't Hoff and Gibbs free energy equations. Additionally, preferential solvation parameters of ACP in the mixtures were also analysed based on the inverse Kirkwood-Buff integrals.