Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design

Stone Isabella B.; Green Jessica A. E. M.; Koefoed Andrew W.; Hornik Ezra S.; Williams Jonathan S.; Adler Gail K.; Williams Gordon H.

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Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design

机译：基于思维基因型，矿物质激素受体拮抗剂驱动的临床试验：研究理由和设计

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《Pharmacogenetics and genomics》 |2021年第4期|共6页
作者
Stone Isabella B.; Green Jessica A. E. M.; Koefoed Andrew W.; Hornik Ezra S.; Williams Jonathan S.; Adler Gail K.; Williams Gordon H.;
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作者单位

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

Harvard Med Sch Brigham &

Womens Hosp Dept Med Div Endocrinol Diabet &

Hypertens Boston MA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
amlodipine; cardiovascular health; eplerenone; genotype; hypertension; mineralocorticoid receptor; personalized medicine; striatin;

机译：氨氯地平;心血管健康;eplerenone;基因型;高血压;矿物质皮质激素;个性化的药物;striatin;

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2. Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST‐Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design [J] . Bulluck Heerajnarain, Fr?hlich Georg M., Mohdnazri Shah, Clinical cardiology. . 2015,第5期

机译：盐皮质激素受体拮抗剂预处理以最小化ST抬高型心肌梗死后的再灌注损伤（MINIMIZE STEMI试验）：原理和研究设计
3. Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease [J] . Pitt Bertram, Anker Stefan D., Boehm Michael, European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2015,第2期

机译：MinerA类激素受体拮抗剂耐受性研究-心力衰竭（ARTS-HF）的原理和设计：在患有糖尿病和/或慢性肾脏病的慢性心力衰竭加重的患者中，使用氟雷农和依普利农的随机研究
4. Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial [J] . Kevin J. Anstrom, For the CleanUP-IPF Study Team, Imre Noth, Respiratory Research . 2020,第1期

机译：抗菌治疗的多中心，务实，开放式随机试验的设计和理由 - 使用务实设计术语特性肺纤维化术语（清除IPF）临床试验研究抗菌治疗策略临床疗效研究
5. A Randomized Clinical Trial of Clinical Decision Support in a Rural Community Health Network Serving Lower Income Individuals: Study Design and Baseline Characteristics [C] . Eric L. EISENSTEIN, David F. LOBACH, Kensaku KAWAMOTO, ITCH (Conference) . 2009

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6. A simulation study of the standard design, the rolling six design, the CRM, and the modified CRM in Phase I clinical trials [D] . Wang, Tao. 2012

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7. Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST‐Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design [O] . Heerajnarain Bulluck, Georg M. Fröhlich, Shah Mohdnazri, 2015

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8. Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study‐Heart Failure (ARTS‐HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease [O] . Pitt Bertram, Anker Stefan D., Böhm Michael, 2015

机译：矿物质类皮质激素受体拮抗剂耐受性研究的基本原理和设计 - 心力衰竭（aRTs-HF）：慢性心力衰竭伴糖尿病和/或慢性肾脏疾病恶化的患者的一项关于苯肾上腺素与依匹乐酮的随机研究
9. Initiating Clinical Trials: A Case Study of a Proposed Clinical Trial for Acute Myocardial Infarction [R] . Hammons, G. T. , Kahan, J. P. 1985

机译：启动临床试验：建议的急性心肌梗死临床试验案例研究

Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design

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