TENANTIOSELECTIVE HALOFUNCTIONALIZATION OF ALKENES

摘要

Electrophilic additions to alkenes provide a robust method for early- and late-stage synthetic modifications, expediting access to a wide range of intermediates. Stereoselective transformations, such as epoxidations, hydroxylations, hydroam-inations, selenations, sulfenylations, oxymercurations, and hydrometalations, form a fundamental class of reactions that serve as essential tools in organic synthesis. The development and scope of one such transformation-enantioselective halofunctionalization of alkenes-is the focus of this chapter.