Indole-3-carbaldehydes Arylhydrazones as Multisite C-Nucleophiles in the Reactions with Quinazoline

摘要

C,C-Coupling of indole-3-carbaldehyde arylhydrazones with quinazoline in trifluoroacetic acid has occurred at position 5 or 7 ' of the hydrazone molecule and has afforded the sigma-adducts. The C,C-coupling has been accompanied by a change in theE-configuration of the C=N bond of the starting hydrazones to theZ-configuration in the formed quinazoline trifluoroacetyl hydrazides.