Radioiodination and biological evaluation of Cimetidine as a new highly selective radiotracer for peptic ulcer disorder detection

摘要

One of the most famous techniques for stomach ulcer imaging is the nuclear imaging technique. We aim to focus on the synthesis of I-125-cimetidine (I-125-cim) as an agent for peptic ulcer imaging. Cimetidine was labeled with Iodine-125 using a different oxidizing agent (Ch-T, NBS). All factors affecting the labeling yield were optimized. The radiochemical yield of I-125-cim was 98 +/- 0.22% at optimum conditions. In vitro stability, in vivo biodistribution of I-125-cimetidine was studied in three groups: control group, pretreated group, and ulcer bearing group. In vivo biodistribution studies of I-125-cim revealed high uptake in the stomach ulcer, reaching about 75.4 +/- 1.2% ID/ g at 15 min post-injection, than pretreated groups compared to the control. The results showed the suitability of using I-125-cimetidine for stomach ulcer imaging.