Efficient synthesis of chromeno[2,3-c]pyrazolyl-pyrazolol(s) in hydrotropic solution and their anti-infective potential

摘要

We report synthesis of chromeno[2,3-c]pyrazolyl-pyrazolol(s) with anti-infective potential in aq. sodium p-toluenesulfonate (NaPTS) hydrotropic solution under ultrasound irradiation at room temperature. Salicylaldehyde (1 mmol), on reaction with 1-phenyl-3-methyl-5-pyrazolone (2 mmol), yielded chromeno[2,3-c]pyrazolyl-pyrazolol(s). Knoevenagel reaction, Michael reaction, intramolecular cyclization, followed by dehydration are key steps involved in the present synthetic protocol. The synthesized compounds were screened for their antimicrobial potential, and molecular docking studies were performed to establish their possible mode of action.