Dr Lars Hufnagel had a problem.His group at the European Molecular Biology Lab studies how developing cells change shape.This requires microscopy that not only gives him high resolution but can deal widi 3D images.And there in lay the problem...that is a big ask.To really understand the mechanical constraints in cellular processes such as cell growth,programmed cell death,and cell differentiation you need a light-field microscopy system which can handle 3D imaging and the incredible speeds at which these processes can occur.Capturing these fast processes is a big challenge in biology.And showing them not only in 2D but in 3D is-next to the needed high resolution-the second main aspect of modern microscopy.”Many important biological processes occur in three dimensions and on millisecond timcscalcs,”says Lars.So,to meet his requirements he took the problem on and decided to develop his own system.And he is pleased with the results.His new light-field microscopy system,developed alongside fellow EMBL group leader Robert Prevedel,overcomes both hurdles at once.
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