Prophylactic role of taurine and its derivatives against diabetes mellitus and its related complications

摘要

Abstract Taurine is a conditionally essential amino acid present in the body in free form. Mammalian taurine is synthesized in the pancreas via the cysteine sulfinic acid pathway. Anti-oxidation and anti-inflammation are two main properties through which it exerts its therapeutic effects. Many studies have shown its excellent therapeutic potential against diabetes mellitus and related complications like diabetic neuropathy, retinopathy, nephropathy, hematological dysfunctions, reproductive dysfunctions, liver and pancreas related complications etc. Not only taurine, a number of its derivatives have also been reported to be important in ameliorating diabetic complications. The present review has been aimed to describe the importance of taurine and its derivatives against diabetic metabolic syndrome and related complications. Highlights ? Taurine exhibits ameliorative effects against diabetes mellitus and related complications. ? The main sources of taurine in vivo are dietary intake and biosynthesis. ? The therapeutic effects of taurine are related to its antioxidant and anti-inflammatory properties. ? Taurine derivatives also have the potential to be used as anti-hyperglycemic drugs.