Effective dietary recommendations could help to prevent age-related cognitive decline

摘要

Implications for practice and research: Effective dietary recommendations to prevent age-related cognitive decline have important public health implications given the high prevalence and large burden of dementia. More prospective studies and clinical trials are needed to further elucidate the role of dietary patterns against neurodegeneration during ageing and to find the most optimal dietary pattern. Context: Dementia is one of the grand challenges of the 21st century. Since no curative therapy is available yet, prevention by lifestyle factors such as diet is of utmost importance. Therefore, effective dietary strategies that can slow down cognitive decline and reduce the incidence of dementia need to be identified. The Mediterranean diet (MedDiet) has been associated with slower cognitive decline and a lower risk of cognitive impair ment and dementia in multiple observational studies. More recently, first observational analyses have shown that better adherence to the Mediter-ranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was associated with a slower rate of cognitive decline and reduced incidence of Alzheimer's disease in US cohorts.