Axitinib plus pembrolizumab in patients with advanced renal-cell carcinoma: Long-term efficacy and safety from a phase Ib trial

Atkins Michael B.; Plimack Elizabeth R.; Puzanov Igor; Fishman Mayer N.; McDermott David F.; Cho Daniel C.; Vaishampayan Ulka; George Saby; Tarazi Jamal C.; Duggan William; Perini Rodolfo; Thakur Mahgull; Fernandez Kathrine C.; Choueiri Toni K.

首页> 外文期刊>European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) >Axitinib plus pembrolizumab in patients with advanced renal-cell carcinoma: Long-term efficacy and safety from a phase Ib trial

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Axitinib plus pembrolizumab in patients with advanced renal-cell carcinoma: Long-term efficacy and safety from a phase Ib trial

机译：Axitinib Plus Pembrolizumab患者晚期肾细胞癌：IB审判中的长期疗效和安全性

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Background: Axitinib plus pembrolizumab showed superior overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) versus sunitinib in a randomised phase III trial in patients with advanced renal-cell carcinoma (RCC). We report long-term efficacy and safety of the axitinib/pembrolizumab from the phase I trial (NCT02133742), after 46-55 months from study initiation (data cut-off date, 23rd July 2019).

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来源
《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)》 |2021年第1期|共10页
作者
Atkins Michael B.; Plimack Elizabeth R.; Puzanov Igor; Fishman Mayer N.; McDermott David F.; Cho Daniel C.; Vaishampayan Ulka; George Saby; Tarazi Jamal C.; Duggan William; Perini Rodolfo; Thakur Mahgull; Fernandez Kathrine C.; Choueiri Toni K.;
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作者单位

Georgetown Lombardi Comprehens Canc Ctr 3800 Reservoir Rd NW Washington DC 20057 USA;

Fox Chase Canc Ctr 333 Cottman Ave Philadelphia PA 19111 USA;

Vanderbilt Univ Med Ctr 1211 Med Ctr Dr Nashville TN USA;

H Lee Moffitt Canc Ctr &

Res Inst 12902 USF Magnolia Dr Tampa FL 33612 USA;

Beth Israel Deaconess Med Ctr 330 Brookline Ave Boston MA 02215 USA;

NYU Langone Med Ctr Perlmutter Canc Ctr 240 E 38th St 19th Floor New York NY 10016 USA;

Wayne State Univ Karmanos Canc Inst 4100 John R St Detroit MI 48201 USA;

Roswell Pk Comprehens Canc Ctr 665 Elm St Buffalo NY 14203 USA;

Pfizer Global Prod Dev Oncol 10777 Sci Ctr Dr San Diego CA 92121 USA;

Pfizer Global Prod Dev Oncol 280 Shennecossett Rd Groton CT 06340 USA;

Merck &

Co Inc 2000 Galloping Hill Rd Kenilworth NJ 07033 USA;

Pfizer Discovery Pk Ramsgate Rd Sandwich CT13 9ND Kent England;

Pfizer Global Prod Dev Oncol 1 Portland St Cambridge MA 02139 USA;

Dana Farber Canc Inst 450 Brookline Ave Boston MA 02215 USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Axitinib; Pembrolizumab; Long-term; Progression-free survival; Overall survival; Renal-cell carcinoma; Safety;

机译：Axitinib;Pembrozumab;长期;无进展生存;总生存率;肾细胞癌;安全;

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2. Alternatives to albumin administration in hepatocellular carcinoma patients undergoing hepatectomy： an open, randomized clinical trial of efficacy and safety [J] . YANG Jian, WANG Wen-tao, YAN Lü-nan, 中华医学杂志：英文版 . 2011,第010期
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5. Phase Ib dose-finding study of axitinib plus pembrolizumab in treatment-na?ve patients with advanced renal cell carcinoma [J] . Michael B Atkins, Shilpa Gupta, Toni K Choueiri, Journal for ImmunoTherapy of Cancer . 2015,第S2期

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Axitinib plus pembrolizumab in patients with advanced renal-cell carcinoma: Long-term efficacy and safety from a phase Ib trial

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