Synthesis and Antimicrobial Activity of New 3-(2-(4-Chlorophenyl)-4-methylthiazol-5-yl) substituted- isoxazol-5-amine, 1-phenyl-1H-pyrazol-5-a mine, and their Derivatives

摘要

New 3-(2-(4-chlorophenyl)-4-methylthiazol-5-yl) substituted aminoisoxazole, am inopyrazole, and their appropriate urea and amide analogs were prepared from thiazole substituted oxopropanenitrile. The structures of newly synthesized compounds were illustrated by infrared, nuclear magnetic resonance, and mass spectroscopic analysis and elemental analyses. The antimicrobial evaluation of analogs was carried out with Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Salmonella ophi). They showed moderate to good activity against both Gram-positive and Gram-negative bacteria.