How to Incorporate a Chemo-Free Interval Into the Management of Metastatic Colorectal Cancer: Discussion

摘要

Axel Grothey, MD For most patients, when I start chemotherapy, I prefer an induction/maintenance approach. I like the combination of a fluoropyrimidine plus beva-cizumab, which I believe is a very strong regimen. There are some patients who do not want to receive treatment for a long duration and who want to avoid maintenance therapy. However, the majority of patients will commit to the idea that as long as there is cancer to treat, they will be receiving some sort of therapy. John L. Marshall, MD Agreed. I take a similar approach, starting with a doublet of capecitabine and bevacizumab, and continuing maintenance with bevacizumab. However, after 6 or 9 months, if the disease remains stable, I might reduce or even skip a bevacizumab dose to try to further minimize treatment while still maintaining the response. But this is something I do several months out, not right away.