Organocatalyzed C-N bond-forming Reactions for the Synthesis of Amines and Amides

摘要

The synthesis of organonitrogen compounds via C-N bond formation emerges as a versatile route for drug discovery. Most of the pharmaceuticals and natural products, which are predominantly used generally contain amine functionalities and amide linkages in their structure. Traditionally, the synthesis is done by using several metal catalysts and hazardous chemicals. The organocatalyzed synthetic protocol provides a sustainable and eco-compatible route for the synthesis of organonitrogen compounds and at the same time also avoids metal contamination. The main aim of this Review is to provide an overview of the organocatalyzed amine and amide synthesis via C-N bond formation reactions. We hope this Review provides valuable information about the organocatalyzed reaction to enable the development of more sustainable routes to form these linkages.