Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

Zhang Heng; Li Lingkang; Hao Miao; Chen Keyan; Lu Yongping; Qi Jing; Chen Wei; Ren Lu; Cai Xintong; Chen Chen; Liu Zhuang; Zhao Bin; Li Zhishuang; Hou Ping

首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

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Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

机译：通过NRF-2 / HO-1途径改善衰老小鼠的病人窦综合征：生病窦综合征的新靶标

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摘要

Ethnopharmacological relevance: Yixin-Fumai granules (YXFMs)-composed of Ginseng quinquefolium (L.) Alph. Wood, Ophiopogon jcuponicus (Thunb.) Ker Gawl, Schisandra arisanensis Hayata, Astragalus aaronsohnianus Eig, Salvia cryptantha Montbret & Aucher ex Benth, and Ligusticum striatum DC-are compound granules used in traditional Chinese medicine to increase heart rate and thus treat bradyarrhythmia. It may be effective in treating sick sinus syndrome (SSS).

机译：民族药理学相关性：益心复脉颗粒（YXFMs）——由西洋参（L.）Alph组成。木材，麦冬葛根、五味子、黄芪、鼠尾草和川芎是中药中用于增加心率从而治疗缓慢性心律失常的复方颗粒。它可能对治疗病态窦房结综合征（SSS）有效。

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来源
《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2021年第1期|共13页
作者
Zhang Heng; Li Lingkang; Hao Miao; Chen Keyan; Lu Yongping; Qi Jing; Chen Wei; Ren Lu; Cai Xintong; Chen Chen; Liu Zhuang; Zhao Bin; Li Zhishuang; Hou Ping;
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作者单位

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

China Med Univ Dept Lab Anim Sci Shenyang 110000 Peoples R China;

China Med Univ Dept NHC Key Lab Reprod Hlth &

Med Genet Liaoning Res Inst Family Planning;

Liaoning Univ Tradit Chinese Med Dept Cardiol Affiliated Hosp Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Dept Cardiol Affiliated Hosp Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

Liaoning Univ Tradit Chinese Med Shenyang 110000 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Sick sinus syndrome; Aging; Nrf-2/HO-1; HCN4; Funny current;

机译：生病的鼻窦综合征;老化;NRF-2 / HO-1;HCN4;有趣的电流;

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1. Value of Combining Left Atrial Diameter and Amino?terminal Pro?brain Natriuretic Peptide to the CHA2DS2?VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation [J] . Bin‑Feng Mo, Qiu‑Fen Lu, Shang‑Biao Lu, 中华医学杂志（英文版） . 2017,第016期
2. Sick sinus syndrome associated with hypopituitarism: a case report and literature review [J] . Dongsheng Zhao, Qing Zhang, Jingping Lu, 生物医学研究杂志（英文版） . 2014,第005期
3. Sinus Node Recovery Time and Abnormal Postpacing Phase in the Aged Patients with Sick Sinus Syndrome [J] . Takao OKIMOTO, Keiji UEDA, Chizuko KAMATA, Japanese heart journal . 1976,第3期

机译：病态窦房结综合征老年患者的窦房结恢复时间和异常的起搏阶段
4. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice [J] . Qiao Yun, Lipovsky Catherine, Hicks Stephanie, Circulation research: a journal of the American Heart Association . 2017,第5期

机译：瞬态凹口激活诱导长期基因表达导致小鼠病患鼻窦综合征的变化
5. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice [J] . Qiao Yun, Lipovsky Catherine, Hicks Stephanie, Circulation research: a journal of the American Heart Association . 2017,第5期

机译：瞬态凹口激活诱导长期基因表达导致小鼠病人窦综合征的变化
6. PHENOTYPICAL OVERLAPPING OF SICK SINUS ANDBRUGADA SYNDROMES IN A FAMILY WITH A NOVELSCN5A MUTATION [C] . FUMIKO YANAGISAWA, YUKEIHIGASHI, HIS A SHIMOJIM International Congress on Electrocardiology . 2005

机译：带有小型突变的家庭中病窦南邦司综合征的表型重叠
7. Assessment by autonomic blockade of age-related changes of the sinus node function and autonomic regulation in sick sinus syndrome [D] . Kuga Keisuke 1988

机译：通过自主神经阻滞评估与年龄相关的病态窦房结的窦房结功能变化和自主神经调节
8. Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish [O] . Jianhua Yan, Hongsong Li, Haisong Bu, 2020

机译：成人斑马鱼的衰老相关的鼻窦骤停血和病人窦综合征
9. Assessment by autonomic blockade of age-related changes of the sinus node function and autonomic regulation in sick sinus syndrome [O] . Kuga Keisuke, クガケイスケ 1988

机译：通过自主神经阻滞评估与年龄相关的病态窦房结的窦房结功能变化和自主神经调节
10. Quantification of the Association of Ventilation Rates with Sick Building Syndrome Symptoms [R] . Fisk, W. J., Mirer, A. G., Mendell, M. J. 2009

机译：量化通气率与病态建筑综合征症状的关系

Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome

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