Synthesis, structure and fungicidal activity of some new threoninamide carbamate derivatives

摘要

In order to find new CAA fungicides, twenty four new threoninamide carbamate derivatives were synthesized. The reaction was optimized. Their structures were confirmed by H-1 NMR, C-13 NMR, single crystal and HRFTMS. Fungicidal activities were evaluated against P capsici and P. cubensi. All of them exhibited excellent activity against Phytophthora capsici in vitro with EC50 values of 0.53 to 20.17 mu g/mL. Notably, compounds 3-11, 3-19 and 3-20 possessed good control effect(>70%) against P capsici in vivo at 6.25 mu g/mL. (C) 2020 Elsevier B.V. All rights reserved.