A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

Hosseini Adele; McLachlan Andrew J.; Lickliter Jason D.

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A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

机译：I期试验，将大麻溶液和单剂量含油溶液和单剂量和多剂量的舌下晶叶中施用的安全性，耐受性和药代动力学进行试验

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Aims This study investigated the safety, tolerability and pharmacokinetics after administration of a specific Cannabis sativa cultivar extract, standardised to cannabidiol (CBD) content as sublingual wafer or oil formulation compared to nabiximols oromucosal spray.

机译：目的：本研究调查了服用特定大麻品种提取物后的安全性、耐受性和药代动力学，与纳比西莫尔口腔粘膜喷雾剂相比，该提取物被标准化为大麻二酚（CBD）含量作为舌下晶片或油制剂。

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来源
《British Journal of Clinical Pharmacology》 |2021年第4期|共8页
作者
Hosseini Adele; McLachlan Andrew J.; Lickliter Jason D.;
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作者单位

BOD Australia Pty Ltd Sydney NSW Australia;

Univ Sydney Fac Med &

Hlth Sydney Pharm Sch Sydney NSW Australia;

Nucleus Network Pty Ltd Melbourne Vic Australia;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
cannabidiol; CBD full spectrum cannabis extract; LINNEA 315CSE extract; pharmacokinetics;

机译：大麻;CBD全谱大麻提取物;Linnea 315cse提取物;药代动力学;

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A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

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