An Efficient Synthesis of(l-Methyl)-2-phenyl-4-quinolones from(N-Methyl)isatoic Anhydride

摘要

The acyl substitution of(N-methyl)isatoic anhydride with MO-dimethylhydroxylamine hydrochloride in CH3CN gave N-methoxy-N-methyl 2-(N-methyl)aminobenzamide,which was treated with ethynyllithium reagents to afford l-[2-(N-methyl)anrino]-3-phenyl-2-propyn-1-ones.The 6-endo cyclization of l-[2-(N-methyl)amino]-3-phenyl-2-propyn-1-ones using NaOCH3 in CH3OH at 65 °C gave various(1-methyl)-2-phenyl-4-quinolone derivatives in high yields.