Development of Transition-Metal-Free Carbon-Carbon and Carbon-Boron Bond-Forming Reactions by Utilizing 1,1-Bis [(Pinacolato)Boryl]Alkanes

摘要

Organoboranes are one of the most versatile reagents and intermediates in organic synthesis, enabling a wide variety of synthetic transformations. Due to their stability, easy accessibility and environmentally benign nature, numerous classes of organoboron reagents have been prepared and utilized under both stoichiometric and catalytic conditions ever since the laboratory preparation of triethylborane by Frankland in 1859. In particular, the boron reagents have enjoyed widespread use as coupling partners in palladium-, nickel-, or copper-catalyzed cross coupling reactions such as Suzuki-Miyaura reaction and Chan-Evans-Lam reaction.