Pharmacokinetics of florfenicol and thiamphenicol after single oral and intravenous, as well as multiple oral administrations to geese

摘要

1. This study evaluated the pharmacokinetic profiles of florfenicol (FF) and thiamphenicol (TP), which are synthetic bacteriostatic antimicrobial drugs, in geese after a single intravenous or oral administration, as well as seven oral doses administered at 12 h intervals. For all treatments, the dose was 30 mg/kg. 2. After single IV administration, clearance and volume of distribution were low (0.23 +/- 0.03 l/h/kg and 0.57 +/- 0.08 l/kg for FF, and 0.23 +/- 0.04 l/h/kg and 0.59 +/- 0.08 l/kg for TP, respectively). The elimination half-life was similar between products and short (2.91 +/- 0.41 and 2.84 +/- 0.64 h for FF and TP, respectively). 3. The single oral administration resulted in efficient absorption (bioavailability of 83.15 +/- 11.48 for FF and 75.21 +/- 19.56% for TP) with high maximal concentrations of 30.47 +/- 2.47 and 20.02 +/- 3.87 mu g/ml for FF and TP, respectively. The area under the curve was 108.36 +/- 14.96 and 101.81 +/- 26.48 mgxh/l for FF and TP, respectively. 4. For both drugs, the two latter parameters were found to be higher compared to earlier studies on terrestrial birds. This suggested that FF and TP may be efficient in treating infections in geese caused by certain bacteria sensitive to chloramphenicol. 5. Neither drug accumulated in tissues following the oral seven doses and no adverse effects were noted in any treated animals. Thus, the selected FF and TP dosage may be considered as a safe treatment for geese.