hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk

Li Jing; Wang Hualong; Du Chongbo; Jin Xiaojing; Geng Yuan; Han Bing; Ma Qinying; Li Quanhai; Wang Qian; Guo Yidi; Wang Mingwei; Yan Baoyong

首页> 外文期刊>Brain research bulletin >hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk

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hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk

机译：HUC-MSCS通过调节C3信号介导的星形细胞 - 微胶质细胞串扰期间的C3信号介导的微胶质极化来改善CUMS诱导的抑郁症

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Background: Major depressive disorder (MDD) has been shown to be related to immune inflammation and the complement system. Previous studies have suggested that human umbilical cord mesenchymal stem cells (hUC-MSCs) play an important role in inflammatory diseases.

机译：背景：主要抑郁症（MDD）已被证明与免疫炎症和补体系统有关。以前的研究表明，人脐部间充质干细胞（HUC-MSCs）在炎性疾病中起重要作用。

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来源
《Brain research bulletin》 |2020年第1期|共11页
作者
Li Jing; Wang Hualong; Du Chongbo; Jin Xiaojing; Geng Yuan; Han Bing; Ma Qinying; Li Quanhai; Wang Qian; Guo Yidi; Wang Mingwei; Yan Baoyong;
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作者单位

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Cell Therapy Lab 89 Dong Gang Rd Shijiazhuang 050031 Hebei Peoples R;

Hebei Med Univ Basic Med Coll Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Basic Med Coll Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Dept Neurol 89 Dong Gang Rd Shijiazhuang 050017 Hebei Peoples R China;

Hebei Med Univ Hosp 1 Cell Therapy Lab 89 Dong Gang Rd Shijiazhuang 050031 Hebei Peoples R;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
hUC-MSCs; Complement C3; Microglial polarization; Neuroinflammation;

机译：HUC-MSCs;补体C3;小胶质末极化;神经引发;

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专利

1. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease [J] . Lian Hong, Litvinchuk Alexandra, Chiang Angie C. -A., The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2016,第2期

机译：通过补体激活的星形胶质细胞-小胶质细胞串扰调节阿尔茨海默氏病小鼠模型中的淀粉样蛋白病理。
2. Electroacupuncture Ameliorates CUMS-induced Depression-like Behavior: Involvement of the Glutamatergic System and Apoptosis in Rats [J] . Guo Qin, Lin Xian-Ming, Di Zhong, Combinatorial chemistry & high throughput screening . 2021,第7期

机译：电针改善了Cums诱导的抑郁症行为：谷氨酸系统涉及大鼠的凋亡
3. MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3 [J] . Xue Yan, Dehao Zeng, He Zhu, Neuropsychiatric Disease and Treatment . 2020,第4期

机译：MiRNA-532-5P通过靶向Stat3调节Cums诱导的抑郁类行为，并调节LPS诱导的促炎细胞因子信号传导
4. Performance Improvement of High-Extinction-Ratio LiNbO{sub}3 Optical Intensity Modulator by Means of Polarization Crosstalk Reduction [C] . Hiroyuki Toda, Katsuya Fukuta, Daisuke Arai, International Topical Meeting on Microwave Photonics . 2007

机译：通过极化串扰降低降低光学强度调制器的高消光比LiNBO {Sub} 3光强度调制器的性能改进
5. Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells [O] . Suchen Qu, Mengqiu Liu, Cheng Cao, 2021

机译：中医甲型式Kai-Xin-SAR改善了Cums诱导的抑郁症状小鼠的神经元炎症并通过抑制BV2细胞的TLR4 / IKK / NF-κB途径减少了炎症因子的表达
6. Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells [O] . Suchen Qu, Mengqiu Liu, Cheng Cao, 2021

机译：中医甲型式Kai-Xin-SAR改善了Cums诱导的抑郁症状小鼠的神经元炎症，并通过抑制BV2细胞的TLR4 / IKK / NF-κB途径减少了炎症因子的表达

hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk

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