Downregulation of lncRNA KCNQ1OT1 relieves traumatic brain injury induced neurological deficits via promoting 'M2' microglia polarization

Liu Na; Sun Haiyan; Li Xuezhong; Cao Wei; Peng Aini; Dong Suyan; Yu Zhixin

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Downregulation of lncRNA KCNQ1OT1 relieves traumatic brain injury induced neurological deficits via promoting 'M2' microglia polarization

机译：LNCRNA KCNQ1OT1的下调通过促进“M2”微胶质胶质偏振来缓解创伤性脑损伤诱导的神经缺陷

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摘要

Background: Microglia-induced neuroinflammation is one of the main characteristics of traumatic brain injury (TBI). Presently, we aim to investigate the role of long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) in TBI-induced neurological deficits and the related mechanism.

机译：背景：微胶质细胞诱导的神经引起炎症是创伤性脑损伤（TBI）的主要特征之一。目前，我们的目的是探讨长期非编码RNA（LNCRNA）KCNQ1重叠转录物1（KCNQ101）在TBI诱导的神经缺陷和相关机制中的作用。

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来源
《Brain research bulletin 》 |2021年第1期| 共12页
作者
Liu Na; Sun Haiyan; Li Xuezhong; Cao Wei; Peng Aini; Dong Suyan; Yu Zhixin;
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作者单位

First Peoples Hosp Zhenjiang Dept Neurol 8 Dianli Rd Zhenjiang 212000 Jiangsu Peoples R China;

Jilin Prov FAW Gen Hosp Dept Neurol Changchun 130000 Jilin Peoples R China;

First Peoples Hosp Zhenjiang Dept Neurol 8 Dianli Rd Zhenjiang 212000 Jiangsu Peoples R China;

First Peoples Hosp Zhenjiang Dept Neurol 8 Dianli Rd Zhenjiang 212000 Jiangsu Peoples R China;

First Peoples Hosp Zhenjiang Dept Neurol 8 Dianli Rd Zhenjiang 212000 Jiangsu Peoples R China;

First Peoples Hosp Zhenjiang Dept Neurol 8 Dianli Rd Zhenjiang 212000 Jiangsu Peoples R China;

First Peoples Hosp Zhenjiang ICU Zhenjiang 212000 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学 ;
关键词
Traumatic brain injury; Microglia; KCNQ1OT1; ceRNA; miR-873-5p;

机译：创伤性脑损伤;微胶质细胞;KCNQ1OT1;CERNA;MIR-873-5P;

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1. Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats [J] . Meng-Xian Pan, Jun-Chun Tang, Rui Liu, 中华创伤杂志（英文版） . 2018 ,第004期
2. Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury [J] . Wei Tang, Xiao-Chuan Sun, Zhi-Jian Huang, 中国神经再生研究（英文版） . 2022 ,第003期
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机译：微胶质细胞的偏振在过氧化物体增殖物激活的受体γ依赖性方式中的M2表型，抑制了小鼠创伤性脑损伤诱导的轴突损伤
6. Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice [J] . Wen Liang, You Wendong, Wang Hao, Journal of neurotrauma . 2018 ,第19期

机译：微胶质细胞的偏振在过氧化物体增殖物激活的受体γ依赖性方式中的M2表型，抑制了小鼠创伤性脑损伤诱导的轴突损伤
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机译：MiR-124通过抑制TLR4途径促进创伤性脑损伤后促进M2的M2偏振和增强的海马神经发生
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机译：大鼠激光诱发的冲击波引起的颅脑外伤：研究爆炸诱发的脑外伤的新型实验室模型
9. An Investigation of Neurological Soft Signs as a Discriminating Factor Between Veterans With Post-Traumatic Stress Disorder, Mild Traumatic Brain Injury, and Co-occuring Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury [D] . Rothman, David Joshua. 2019

机译：创伤后应激障碍，轻度创伤性脑损伤，并发创伤后应激障碍和轻度创伤性脑损伤的退伍军人之间作为区分因素的神经软体征的调查
10. Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization [O] . Mei Jiang, Xinghui Liu, Denghai Zhang, 2018

机译：Celastrol治疗可通过促进IL-33 / ST2轴介导的小胶质细胞/巨噬细胞M2极化来预防急性缺血性中风引起的脑损伤
11. P2.03-34 Fractalkine Attenuate Irradiation-Induced Brain Injury Through Promoting the M2 Polarization of Microglia [O] . H. Pan, F. Tong, H. Li, 2019

机译：p2.03-34裂缝率通过促进微胶质细胞的M2偏振来衰减辐照诱导的脑损伤
12. Increase in Blood-Brain Barrier Perrmeability, Oxidative Stress, and Activated Microglia in a Rat Model of Blast-Induced Traumatic Brain Injury [R] . Readnower, R. D., Chavko, M., Adeeb, S., 2010

机译：爆炸致颅脑损伤大鼠血脑屏障通透性，氧化应激和活化小胶质细胞增加

Downregulation of lncRNA KCNQ1OT1 relieves traumatic brain injury induced neurological deficits via promoting 'M2' microglia polarization

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