Comment on maternal alcohol consumption--Re: 'Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome: environmental connection'.

摘要

Toppari and co-authors recently published a review on "the environmental connection" of cryptorchidism and hypospadias, including the potential adverse effect of alcohol (Toppari et al., 2010). Based on an article by Damgaard et al., 2007, they conclude that: "mothers' alcohol consumption caused a dose-dependent increase in the risk of cryptorchidism" (Damgaard et al., 2007). We are not convinced that the article by Damgaard and co-authors actually present data that indicate a dose-response relation, and furthermore, it is not the only paper published on this topic (Jensen et al., 2007; Mon-graw-Chaffin et al., 2008; Strandberg-Larsen et al., 2009).