Hadamard Transform CE

摘要

Despite all the advantages of CE, the technique's application is limited, in part, because of poor detection limits. One way to improve sensitivity is with multiplexing techniques, which are powerful mathematical approaches for detecting small amounts of molecules in very dilute solutions or improving the resolution of spectroscopic methods. Incorporating Fourier transform (FT), for example, with techniques such as NMR, IR absorption, and ion cyclotron resonance MS has revolutionized chemical analysis. However, in the separation sciences arena, there are only a few examples of multiplexing methods: cross-correlation GC (1), Shah convolution FT electrophoresis (2), and cross-correlation electrophoresis (3, 4). In this article, we introduce Hadamard transform CE, an approach that offers improved sensitivity.