Amino-functionalized mesoporous bioactive glass for drug delivery

摘要

An amino-functionalized mesoporous bioactive glass (N-MBG) with a high drug loading capacity and longer drug release time was successfully prepared by using 3-aminopropyltriethoxysilane (APTES) in a short-time chemical reaction. The drug release performance of an. MBG. and the. N-MBG were studied by loading gentamicin sulfate (GS) in a simulated body fluid solution. The results. showed that the surface area of the. N-MBG increases to 355.01 m(2) g(-1) after amination at 80 degrees C for 1 h compared with that of the MBG(288.07 m(2) g(-1)). Meanwhile, the surface zeta-potential of the N-MBG charges from the original negative charge (-10.06mV) to the positive charge (+5.30mV). Furthermore, the GS loading rate of the. N-MBG is up to 62.92 +/- 2.02%, higher than that of the MBG (48.90 +/- 1.71%). In addition, the. N-MBG has a longer drug release period. and the seven-day accumulative release from the. N-MBG reached. only 45.9 +/- 1.8%, significantly lower than that of the MBG, 60.7 +/- 2.3%. In vitro bioactivity tests suggested that the. N-MBG exhibited good. biological activity. In conclusion, the N-MBG with a higher loading capacity and longer drug release time can serve as a promising candidate as a. drug carrier.