Research on pharmacokinetics related genetic polymorphism among japanese population (pharma SNP Consortium :PSC)

摘要

The 43 member companies of the Japan Pharmaceutical Manufactures Association established Pharma SNP Consortium (PSC),a non-profit organization,which will implement research projects over three years between 2000-2003 with a total budget of 1 billion yen.The following are concrete,protection of privacy the PCS:Standardization to collect samples from human donors;informed consent,protection of privacy (anonymity,information management system.etc.),ethics committe,and procedures(blood samplig,storage,etc.).And the analysis on gene polymorphisms(SNPs)related with pharmacokineties;to identify SNPs of approximately 180 pharmacokinetics related genes,whicha are drug metabolizing enzymes and drug transporters,to analyze the allelic frequency of SNPs on a general Japanese population group composed of about 800 individuals,to generate a database for the analysis of SNPs allelic fequency,and to express variants in insect cells,analyze their function and ezamine the influence on the drug responses.