Renal tubular epithelocytic changes in hypercysteinemia and experimental chronic renal failure

摘要

One group of adult male Wistar rats received DL-homocysteine, 13.4 mg/kg body weight every day (an HC-group) while the rats underwent subtotal nephrectomy (a SN-group) and were killed 3 weeks later. Both light and electron microscopies were used to analyze obtained renal specimens. A total loss of the brush border in some proximal tubular (PT) cells and an increase of autophagosomes and emergence of the loci of disorganized cytoplasm were observed in the HC-group, while in the SN-group there was a significant increase in the number and size of secondary lysosomes and of foci of the cytoplasmic disorganization.