Periodontal response to orthodontic tooth movement in diabetes‐induced rats with or without periodontal disease

摘要

Abstract Background Systemic conditions can influence orthodontic tooth movement. This study evaluates histologic periodontal responses to orthodontic tooth movement in diabetes‐induced rats with or without periodontal disease. Methods Forty Wistar rats were divided according their systemic condition (SC) into diabetic (D) and non‐diabetic (ND) groups. Each group was subdivided into control (C), orthodontic tooth movement (OM), ligature‐induced periodontitis (P) and ligature‐induced periodontitis with orthodontic movement (P+OM) groups. Diabetes mellitus (DM) was induced with alloxan monohydrate, and after 30 days, the P group received a cotton ligature around their first lower molar crown. An orthodontic device was placed in OM and P+OM groups for 7 days, and the animals were then euthanized. Results Differences in OM between D and ND groups were not significant (6.87± 3.55?mm and 6.81 ± 3.28?mm, respectively), but intragroup analysis revealed statistically significant differences between the P+OM groups for both SCs. Bone loss was greater in the D group (0.16 ± 0.07 mm 2 ) than in the ND group (0.10 ± 0.03 mm 2 ). In intragroup analysis of the D condition, the P+OM group differed statistically from the other groups, while in the ND condition, the P+OM group was different from the C and OM groups. There was a statistically significant difference in bone density between D and ND conditions (18.03 ± 8.09% and 22.53 ± 7.72%) in the C, P, and P+OM groups. Conclusion DM has deleterious effects on bone density and bone loss in the furcation region. These effects are maximized when associated with ligature‐induced periodontitis with orthodontic movement.