Determining the specificity of anti-HIV-1 gRNAs used for CRISPR/Cas9 cure strategies: Uncovering on- and off-target effects using GUIDE-seq

Sullivan Neil; Dampier Will; Homan Greg; Allen Alexander; Atkins Andrew; Chung Cheng-Han; Pirrone Vanessa; Passic Shendra; Williams Jean; Zhong Wen; Kercher Katherine; Szep Zsofia; Jacobson Jeffrey; Nonnemacher Michael; Wigdahl Brian

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Determining the specificity of anti-HIV-1 gRNAs used for CRISPR/Cas9 cure strategies: Uncovering on- and off-target effects using GUIDE-seq

机译：确定用于CRISPR / CAS9治愈策略的抗HIV-1 GRNA的特异性：使用指南-SEQ揭示和脱靶效果

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来源
《Journal of neurovirology》 |2018年第1期|共2页
作者
Sullivan Neil; Dampier Will; Homan Greg; Allen Alexander; Atkins Andrew; Chung Cheng-Han; Pirrone Vanessa; Passic Shendra; Williams Jean; Zhong Wen; Kercher Katherine; Szep Zsofia; Jacobson Jeffrey; Nonnemacher Michael; Wigdahl Brian;
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作者单位

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Div Infect Dis &

HIV Med Philadelphia PA 19104 USA;

Temple Univ Lewis Katz Sch Med Dept Neurosci Philadelphia PA 19122 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

Drexel Univ Coll Med Dept Microbiol &

Immunol Philadelphia PA 19104 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
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1. Determining the specificity of anti-HIV-1 gRNAs used for CRISPR/Cas9 cure strategies: Uncovering on- and off-target effects using GUIDE-seq [J] . Sullivan Neil, Dampier Will, Homan Greg, Journal of neurovirology . 2018,第Suppla1期

机译：确定用于CRISPR / CAS9治愈策略的抗HIV-1 GRNA的特异性：使用指南-SEQ揭示和脱靶效果
2. Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On- and Off-Target Damage Techniques for Detecting, Predicting, and Mitigating the On- and off-target Effects of Cas9 Editing [J] . Newman Anthony, Storrs Lora, Burgio Gaetan BioEssays : . 2020,第9期

机译：Cas9削减和后果; 检测，预测和减轻CRISPR / CAS9和偏离目标损坏技术，用于检测，预测和减轻CAS9编辑的开启和离心效果
3. Impact of human genetic variation and DNA accessibility on the off-target effects of anti-HIV-1 gRNA design [J] . Chung Cheng-Han, Nonnemacher Michael, Wigdahl Brian, Journal of neurovirology . 2018,第Suppla1期

机译：人类遗传变异和DNA可访问性对抗HIV-1 GRNA设计脱靶效应的影响
4. Searching for Potential gRNA Off-Target Sites for CRISPR/Cas9 Using Automata Processing Across Different Platforms [C] . Chunkun Bo, Vinh Dang, Elaheh Sadredini, IEEE International Symposium on High Performance Computer Architecture . 2018

机译：使用跨不同平台的自动机处理搜索CRISPR / Cas9的潜在gRNA脱靶位点
5. Determining HIV-1 Quasispecies Genomic Variability to Optimize gRNA Excision Using the CRISPR/Cas9 Gene Editing System [D] . DeSimone, Matthew F. 2015

机译：使用CRISPR / Cas9基因编辑系统确定HIV-1准种基因组变异性以优化gRNA切除
6. Strategies to Increase On-Target and Reduce Off-Target Effects of the CRISPR/Cas9 System in Plants [O] . Zahra Hajiahmadi, Ali Movahedi, Hui Wei, 2019

机译：提高植物中CRISPR / Cas9系统的靶上效应和减少脱靶效应的策略
7. Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter [O] . Jian-Hua Zhang, Mritunjay Pandey, John F. Kahler, 2014

机译：通过靶特异性DNA报告改善CRISPR / CAS9和GRNA的特异性和功效

Determining the specificity of anti-HIV-1 gRNAs used for CRISPR/Cas9 cure strategies: Uncovering on- and off-target effects using GUIDE-seq

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